List four ways coronary artery disesase can lead to secondary mitral regurgitation.

List four ways coronary artery disesase can lead to secondary mitral regurgitation.

1. Dilation of the left ventricle can lead to annular dilation.
2. Posterior wall akinesis or dyskinesis may restrict motion of the posterior leaflet.
3. Papillary muscle dysfunction or rupture can occur secondary to myocardial infarction, leading to mitral regurgitation.
4. Poor left ventricular systolic performance can lead to incomplete mitral leaflet closure.