How is lobular neoplasia managed?
How is lobular neoplasia managed?
The management has evolved over time from bilateral mastectomy (due to future risk), excisional biopsy (due to potential upgrade to breast cancer) and imaging follow-up (since risk for cancer is observed away from site of biopsy). Current recommendations for excision or imaging follow-up depend on radiology-pathology concordance and method of detection.
For instance, when incidental on pathology and other histology present on H&E is concordant for the imaging-finding targeted for biopsy, lobular neoplasia can be followed with imaging. However, when identified by MRI, excision is currently recommended.
Given risk of future breast cancer, referral for high-risk assessment is suggested for all patients with lobular neoplasia.